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A model of pulldown alignments from SssI-treated DNA improves DNA methylation prediction

BACKGROUND: Protein pulldown using Methyl-CpG binding domain (MBD) proteins followed by high-throughput sequencing is a common method to determine DNA methylation. Algorithms have been developed to estimate absolute methylation level from read coverage generated by affinity enrichment-based techniqu...

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Publicat a:BMC Bioinformatics
Autors principals: Moreland, Blythe S., Oman, Kenji M., Bundschuh, Ralf
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700779/
https://ncbi.nlm.nih.gov/pubmed/31426747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-3011-2
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