Oral Immunization with Soybean Storage Protein Containing Amyloid-β 4–10 Prevents Spatial Learning Decline

 Amyloid-β (Aβ) plays a central role in the pathogenesis of Alzheimer’s disease (AD). Because AD pathologies begin two decades before the onset of dementia, prevention of Aβ amyloidosis has been proposed as a mean to block the pathological cascade. Here, we generate a transgenic plant-based vaccine,...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: Kawarabayashi, Takeshi, Terakawa, Teruhiko, Takahashi, Atsushi, Hasegawa, Hisakazu, Narita, Sakiko, Sato, Kaoru, Nakamura, Takumi, Seino, Yusuke, Hirohata, Mie, Baba, Nobue, Ueda, Tetsuya, Harigaya, Yasuo, Kametani, Fuyuki, Maruyama, Nobuyuki, Ishimoto, Masao, St. George-Hyslop, Peter, Shoji, Mikio
Médium: Artigo
Jazyk:Inglês
Vydáno: IOS Press 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700641/
https://ncbi.nlm.nih.gov/pubmed/31177217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190023
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