Exploratory study of the effect of one week of orally administered CNSA-001 (sepiapterin) on CNS levels of tetrahydrobiopterin, dihydrobiopterin and monoamine neurotransmitter metabolites in healthy volunteers

Tetrahydrobiopterin (BH(4)) is a cofactor for the enzymes tyrosine hydroxylase and tryptophan hydroxylase, the rate-limiting enzymes in the production of the neurotransmitters, dopamine and serotonin, respectively, in the central nervous system (CNS). Administration of BH(4) is used clinically withi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Mol Genet Metab Rep
Autores principales: Smith, Neil, Longo, Nicola, Levert, Keith, Hyland, Keith, Blau, Nenad
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700519/
https://ncbi.nlm.nih.gov/pubmed/31453106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgmr.2019.100500
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares