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CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset

Variable, glutamine-encoding, CAA interruptions indicate that a property of the uninterrupted HTT CAG repeat sequence, distinct from the length of huntingtin’s polyglutamine segment, dictates the rate at which Huntington’s disease (HD) develops. The timing of onset shows no significant association w...

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Bibliografske podrobnosti
izdano v:Cell
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700281/
https://ncbi.nlm.nih.gov/pubmed/31398342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.06.036
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