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The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis

Renal fibrosis is accompanied by the progression of chronic kidney disease. Despite a number of past and ongoing studies, our understanding of the underlying mechanisms remains elusive. Here we explored the progression of renal fibrosis using a mouse model of unilateral ureter obstruction. We found...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Koyano, Takayuki, Namba, Masumi, Kobayashi, Tomoe, Nakakuni, Kyomi, Nakano, Daisuke, Fukushima, Masaki, Nishiyama, Akira, Matsuyama, Makoto
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700145/
https://ncbi.nlm.nih.gov/pubmed/31427681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48557-8
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