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The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis

Renal fibrosis is accompanied by the progression of chronic kidney disease. Despite a number of past and ongoing studies, our understanding of the underlying mechanisms remains elusive. Here we explored the progression of renal fibrosis using a mouse model of unilateral ureter obstruction. We found...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koyano, Takayuki, Namba, Masumi, Kobayashi, Tomoe, Nakakuni, Kyomi, Nakano, Daisuke, Fukushima, Masaki, Nishiyama, Akira, Matsuyama, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700145/
https://ncbi.nlm.nih.gov/pubmed/31427681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48557-8
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