Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production

Lung adenocarcinoma (LUAD), which comprises over 50% of all cases of non-small-cell lung cancer, has a poor prognosis and requires novel therapeutic approaches. The sonic Hedgehog (Shh) pathway, which plays a crucial role in differentiation, proliferation, and survival of cancer cells, is likely to...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Fan, Jiajun, Zhang, Xuyao, Wang, Shaofei, Chen, Wei, Li, Yubin, Zeng, Xian, Wang, Yichen, Luan, Jingyun, Li, Li, Wang, Ziyu, Sun, Xilin, Shen, Baozhong, Ju, Dianwen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700102/
https://ncbi.nlm.nih.gov/pubmed/31427566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1840-6
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