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Citrullination facilitates cross-reactivity of rheumatoid factor with non-IgG1 Fc epitopes in rheumatoid arthritis

Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs) are the two most prevalent autoantibodies in rheumatoid arthritis (RA), and are thought to have distinct autoantigen targets. Whilst RF targets the Fc region of antibodies, ACPAs target a far broader spectrum of citrullinated p...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Trela, Malgorzata, Perera, Shantha, Sheeran, Thomas, Rylance, Paul, Nelson, Paul N., Attridge, Kesley
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700074/
https://ncbi.nlm.nih.gov/pubmed/31427662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48176-3
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