Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity

Oxysterol-binding protein like 2 (OSBPL2) was identified as a novel causal gene for autosomal dominant nonsyndromic hearing loss. However, the pathogenesis of OSBPL2 deficits in ADNSHL was still unclear. The function of OSBPL2 as a lipid-sensing regulator in multiple cellular processes suggested tha...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Wang, Hongshun, Lin, Changsong, Yao, Jun, Shi, Hairong, Zhang, Cui, Wei, Qinjun, Lu, Yajie, Chen, Zhibin, Xing, Guangqian, Cao, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700064/
https://ncbi.nlm.nih.gov/pubmed/31427568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1858-9
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