Impact of KRAS and TP53 Co-Mutations on Outcomes After First-Line Systemic Therapy Among Patients With STK11-Mutated Advanced Non–Small-Cell Lung Cancer

PURPOSE: The STK11 gene encodes a serine/threonine protein kinase that regulates cell polarity and functions as a tumor suppressor. Patients with non–small-cell lung cancer (NSCLC) and STK11 mutations often have other co-mutations. We evaluated the impact of KRAS and TP53 co-mutations on outcomes af...

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Dettagli Bibliografici
Pubblicato in:JCO Precis Oncol
Autori principali: Bange, Erin, Marmarelis, Melina E., Hwang, Wei-Ting, Yang, Yu-Xiao, Thompson, Jeffrey C., Rosenbaum, Jason, Bauml, Joshua M., Ciunci, Christine, Alley, Evan W., Cohen, Roger B., Langer, Corey J., Carpenter, Erica, Aggarwal, Charu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2019
Soggetti:
Original Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699781/
https://ncbi.nlm.nih.gov/pubmed/31428721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00326
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