Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer

Oncogenic KRAS mutation plays a key role in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis with nearly 95% of PDAC harboring mutation-activated KRAS, which has been considered an undruggable target. Doublecortin-like kinase 1 (DCLK1) is often overexpressed in pancreatic cancer, and recent stu...

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Bibliographic Details
Published in:J Oncol
Main Authors: Qu, Dongfeng, Weygant, Nathaniel, Yao, Jiannan, Chandrakesan, Parthasarathy, Berry, William L., May, Randal, Pitts, Kamille, Husain, Sanam, Lightfoot, Stan, Li, Min, Wang, Timothy C., An, Guangyu, Clendenin, Cynthia, Stanger, Ben Z., Houchen, Courtney W.
Format: Artigo
Language:Inglês
Published: Hindawi 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699308/
https://ncbi.nlm.nih.gov/pubmed/31467540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/6402925
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