Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors

The development of CRISPR/Cas9-mediated base editors (BEs) provided a versatile tool for precise genome editing. The recently developed xCas9-derived base editors (xBEs) that recognize the NG PAM substantially expand the targeting scope in the genome, while their editing efficiency needs to be impro...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Liu, Xinyi, Li, Guanglei, Zhou, Xueliang, Qiao, Yunbo, Wang, Ruixuan, Tang, Shaohui, Liu, Jianqiao, Wang, Lisheng, Huang, Xingxu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699141/
https://ncbi.nlm.nih.gov/pubmed/31400605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.06.024
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