A CRISPR/Cas9 screen identifies the histone demethylase MINA53 as a novel HIV-1 latency-promoting gene (LPG)

Although combination antiretroviral therapy is potent to block active replication of HIV-1 in AIDS patients, HIV-1 persists as transcriptionally inactive proviruses in infected cells. These HIV-1 latent reservoirs remain a major obstacle for clearance of HIV-1. Investigation of host factors regulati...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Huang, Huachao, Kong, Weili, Jean, Maxime, Fiches, Guillaume, Zhou, Dawei, Hayashi, Tsuyoshi, Que, Jianwen, Santoso, Netty, Zhu, Jian
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698651/
https://ncbi.nlm.nih.gov/pubmed/31165872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz493
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