A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2

Fanconi Anemia (FA) clinical phenotypes are heterogenous and rely on a mutation in one of the 22 FANC genes (FANCA-W) involved in a common interstrand DNA crosslink-repair pathway. A critical step in the activation of FA pathway is the monoubiquitination of FANCD2 and its binding partner FANCI. To b...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Dubois, Emilie L, Guitton-Sert, Laure, Béliveau, Mariline, Parmar, Kalindi, Chagraoui, Jalila, Vignard, Julien, Pauty, Joris, Caron, Marie-Christine, Coulombe, Yan, Buisson, Rémi, Jacquet, Karine, Gamblin, Clémence, Gao, Yuandi, Laprise, Patrick, Lebel, Michel, Sauvageau, Guy, D. d’Andrea, Alan, Masson, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698648/
https://ncbi.nlm.nih.gov/pubmed/31219578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz514
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