11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy

BACKGROUND: Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects including glucocorticoid-induced osteoporosis (GIOP). 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a bi...

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Библиографические подробности
Опубликовано в: :Arthritis Res Ther
Главные авторы: Fenton, C. G., Doig, C. L., Fareed, S., Naylor, A., Morrell, A. P., Addison, O., Wehmeyer, C., Buckley, C. D., Cooper, M. S., Lavery, G. G., Raza, K., Hardy, R. S.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698000/
https://ncbi.nlm.nih.gov/pubmed/31420008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1972-1
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