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The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases

BACKGROUND: Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby increasing oxidative stress in the microenvironment. This way, activated fibroblast...

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Bibliographische Detailangaben
Veröffentlicht in:BMC Cancer
Hauptverfasser: Jezierska-Drutel, Agnieszka, Attaran, Shireen, Hopkins, Barbara L., Skoko, John J., Rosenzweig, Steven A., Neumann, Carola A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697950/
https://ncbi.nlm.nih.gov/pubmed/31419957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6031-4
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