The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases

BACKGROUND: Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby increasing oxidative stress in the microenvironment. This way, activated fibroblast...

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Publicat a:BMC Cancer
Autors principals: Jezierska-Drutel, Agnieszka, Attaran, Shireen, Hopkins, Barbara L., Skoko, John J., Rosenzweig, Steven A., Neumann, Carola A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697950/
https://ncbi.nlm.nih.gov/pubmed/31419957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6031-4
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