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Hippocampal deletion of Na(V)1.1 channels in mice causes thermal seizures and cognitive deficit characteristic of Dravet Syndrome
Dravet Syndrome is a severe childhood epileptic disorder caused by haploinsufficiency of the SCN1A gene encoding brain voltage-gated sodium channel Na(V)1.1. Symptoms include treatment-refractory epilepsy, cognitive impairment, autistic-like behavior, and premature death. The specific loci of Na(V)1...
में बचाया:
| में प्रकाशित: | Proc Natl Acad Sci U S A |
|---|---|
| मुख्य लेखकों: | , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
National Academy of Sciences
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6697805/ https://ncbi.nlm.nih.gov/pubmed/31346088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906833116 |
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