IL-23 producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven pro-inflammatory epithelial cell response

Several cytokines maintain intestinal health, but precise inter-cellular communication networks remain poorly understood. Macrophages are immune sentinels of the intestinal tissue, critical for gut homeostasis. Here we show that in a murine IBD model based on macrophage-restricted Interleukin 10 (IL...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Immunol
Prif Awduron: Bernshtein, Biana, Curato, Caterina, Ioannou, Marianna, Thaiss, Christoph A, Gross-Vered, Mor, Kolesnikov, Masha, Wang, Qian, David, Eyal, Chappell-Maor, Louise, Harmelin, Alon, Elinav, Eran, Thakker, Paresh, Papayannopoulos, Venizelos, Jung, Steffen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697185/
https://ncbi.nlm.nih.gov/pubmed/31201258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aau6571
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