Cytokine regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis

Even though the TET enzymes catalyze the generation of 5-hydroxymethyl-cytosines required for lineage commitment and subsequent differentiation of stem cells into erythroid cells, the mechanisms that link extra-cellular signals to TET activation and DNA hydroxymethylation are unknown. We demonstrate...

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書誌詳細
出版年:Cancer Discov
主要な著者: Jeong, Jong Jin, Gu, Xiaorong, Nie, Ji, Sundaravel, Sriram, Liu, Hui, Kuo, Wen-Liang, Bhagat, Tushar D, Pradhan, Kith, Cao, John, Nischal, Sangeeta, McGraw, Kathy L., Bhattacharyya, Sanchari, Bishop, Michael R., Artz, Andrew, Thirman, Michael J., Moliterno, Alison, Ji, Peng, Levine, Ross L., Godley, Lucy A., Steidl, Ulrich, Bieker, James J., List, Alan F., Saunthararajah, Yogen, He, Chuan, Verma, Amit, Wickrema, Amittha
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697164/
https://ncbi.nlm.nih.gov/pubmed/30944118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1138
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