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Laser-Capture Microdissection and RNA Extraction from Perfusion-Fixed Cartilage and Bone Tissue from Mice Implanted with Human iPSC-Derived MSCs in a Calvarial Defect Model

Laser-capture microdissection (LCM) coupled to downstream RNA analysis poses unique difficulties for the evaluation of mineralized tissues. A rapid protocol was thus developed to enable sufficient integrity of bone and cartilage tissue for reliable sectioning, while minimizing RNA loss associated wi...

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Detalhes bibliográficos
Publicado no:Methods Mol Biol
Main Authors: Xin, Xiaonan, Jiang, Xi, Lichtler, Alexander, Kronenberg, Mark, Rowe, David, Pachter, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697139/
https://ncbi.nlm.nih.gov/pubmed/29344873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-7558-7_22
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