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Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing (RIPiT-Seq)

RNA immunoprecipitation in tandem (RIPiT) is a method for enriching RNA footprints of a pair of proteins within an RNA:protein (RNP) complex. RIPiT employs two purification steps. First, immunoprecipitation of a tagged RNP subunit is followed by mild RNase digestion and subsequent non-denaturing aff...

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Bibliographic Details
Published in:J Vis Exp
Main Authors: Woodward, Lauren, Gangras, Pooja, Singh, Guramrit
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697088/
https://ncbi.nlm.nih.gov/pubmed/31355789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59913
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