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Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice

Gain-of-function mutations in TRPC6 cause familial focal segmental glomerulosclerosis, and TRPC6 is upregulated in glomerular diseases including diabetic kidney disease. We studied the effect of systemic TRPC6 knockout in the Akita model of type 1 diabetes. Knockout of TRPC6 inhibited albuminuria in...

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Bibliografische gegevens
Gepubliceerd in:Kidney Int
Hoofdauteurs: Wang, Liming, Chang, Jae-Hyung, Buckley, Anne F., Spurney, Robert F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696997/
https://ncbi.nlm.nih.gov/pubmed/30665571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.09.026
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