Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

In diabetic patients, high blood glucose induces alterations in retinal function and can lead to visual impairment due to diabetic retinopathy. In immortalized retinal pigment epithelial (RPE) cultures, high glucose concentrations are shown to lead to impairment in epithelial barrier properties. For...

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Udgivet i:Int J Mol Sci
Main Authors: Kiamehr, Mostafa, Klettner, Alexa, Richert, Elisabeth, Koskela, Ali, Koistinen, Arto, Skottman, Heli, Kaarniranta, Kai, Aalto-Setälä, Katriina, Juuti-Uusitalo, Kati
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696227/
https://ncbi.nlm.nih.gov/pubmed/31375001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20153773
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