Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

The inflammasome is a multiprotein complex assembled in response to Pathogen Associated Molecular Patterns (PAMPs) and Danger Associated Molecular Patterns (DAMPs). Inflammasome activation occurs through a two-step mechanism, with the first signal facilitating priming of inflammasome components whil...

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Pubblicato in:Cell Death Dis
Autori principali: Talty, Aaron, Deegan, Shane, Ljujic, Mila, Mnich, Katarzyna, Naicker, Serika D., Quandt, Dagmar, Zeng, Qingping, Patterson, John B., Gorman, Adrienne M., Griffin, Matthew D., Samali, Afshin, Logue, Susan E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695440/
https://ncbi.nlm.nih.gov/pubmed/31417078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1847-z
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