Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants

BACKGROUND: Based on the association of common GLIS3 variants with various forms of diabetes and the biological role of GLIS3 in beta-cells, we sequenced GLIS3 in non-diabetic and diabetic Danes to investigate the effect of rare missense variants on glucose metabolism. METHODS: We sequenced 53 patie...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Sun, Jihua, Have, Christian Theil, Hollensted, Mette, Grarup, Niels, Linneberg, Allan, Pedersen, Oluf, Nielsen, Jens Steen, Rungby, Jørgen, Christensen, Cramer, Brandslund, Ivan, Kristiansen, Karsten, Jun, Wang, Hansen, Torben, Gjesing, Anette P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695102/
https://ncbi.nlm.nih.gov/pubmed/31415576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220805
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