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Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants
BACKGROUND: Based on the association of common GLIS3 variants with various forms of diabetes and the biological role of GLIS3 in beta-cells, we sequenced GLIS3 in non-diabetic and diabetic Danes to investigate the effect of rare missense variants on glucose metabolism. METHODS: We sequenced 53 patie...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6695102/ https://ncbi.nlm.nih.gov/pubmed/31415576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220805 |
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