Replication-Defective West Nile Virus with NS1 Deletion as a New Vaccine Platform for Flavivirus

We previously produced a replication-defective West Nile virus (WNV) lacking NS1 (WNV-ΔNS1) that could propagate at low levels (10(5) infectious units [IU]/ml) in a 293T cell line expressing wild-type (WT) NS1. This finding indicates the potential of developing WNV-ΔNS1 as a noninfectious vaccine. T...

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Bibliographic Details
Published in:J Virol
Main Authors: Li, Na, Zhang, Ya-Nan, Deng, Cheng-Lin, Shi, Pei-Yong, Yuan, Zhi-Ming, Zhang, Bo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694808/
https://ncbi.nlm.nih.gov/pubmed/31189715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00720-19
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