PDZ Scaffold Protein CAL Couples with Metabotropic Glutamate Receptor 5 to Protect Against Cell Apoptosis and Is a Potential Target in the Treatment of Parkinson’s Disease

Targeting mGluR5 has been an attractive strategy to modulate glutamate excitotoxicity for neuroprotection. Although human clinical trials using mGluR5 negative allosteric modulators (NAMs) have included some disappointments, recent investigations have added several more attractive small molecules to...

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Publicado en:Neurotherapeutics
Autores principales: Luo, Wen Yuan, Xing, Su Qian, Zhu, Ping, Zhang, Chen Guang, Yang, Hui Min, Van Halm-Lutterodt, Nicholas, Gu, Li, Zhang, Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2019
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694344/
https://ncbi.nlm.nih.gov/pubmed/31073978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00730-7
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