PDZ Scaffold Protein CAL Couples with Metabotropic Glutamate Receptor 5 to Protect Against Cell Apoptosis and Is a Potential Target in the Treatment of Parkinson’s Disease

Targeting mGluR5 has been an attractive strategy to modulate glutamate excitotoxicity for neuroprotection. Although human clinical trials using mGluR5 negative allosteric modulators (NAMs) have included some disappointments, recent investigations have added several more attractive small molecules to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurotherapeutics
Prif Awduron: Luo, Wen Yuan, Xing, Su Qian, Zhu, Ping, Zhang, Chen Guang, Yang, Hui Min, Van Halm-Lutterodt, Nicholas, Gu, Li, Zhang, Hong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer International Publishing 2019
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694344/
https://ncbi.nlm.nih.gov/pubmed/31073978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00730-7
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg