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Augmentation of IFN-γ(+) CD8(+) T cell responses correlates with survival of HCC patients on sorafenib therapy

BACKGROUND: Sorafenib has been shown to reduce the extent of immunosuppression in patients with hepatocellular carcinoma (HCC). The rationale of this investigation was to identify biomarkers that can predict treatment efficacy of sorafenib in HCC patients and to unravel the mechanism by which sorafe...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Kalathil, Suresh Gopi, Hutson, Alan, Barbi, Joseph, Iyer, Renuka, Thanavala, Yasmin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693832/
https://ncbi.nlm.nih.gov/pubmed/31391334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130116
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