Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma

Despite the propensity for gastric and esophageal adenocarcinomas to select for recurrent missense mutations in TP53, the precise functional consequence of these mutations remains unclear. Here we report that endogenous mRNA and protein levels of mutant p53 were elevated in cell lines and patients w...

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Pubblicato in:JCI Insight
Autori principali: Sethi, Nilay, Kikuchi, Osamu, McFarland, James, Zhang, Yanxi, Chung, Max, Kafker, Nicholas, Islam, Mirazul, Lampson, Benjamin, Chakraborty, Abhishek, Kaelin, William G., Bass, Adam J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693823/
https://ncbi.nlm.nih.gov/pubmed/31391338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128439
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