Chondroitinase Improves Anatomical and Functional Outcomes After Primate Spinal Cord Injury

Inhibitory extracellular matrices form around mature neurons as perineuronal nets containing chondroitin sulfate proteoglycans (CSPGs) that limit axonal sprouting after CNS injury. The enzyme chondroitinase (Chase) degrades the inhibitory CSPGs and improves axonal sprouting and functional recovery a...

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Foilsithe in:Nat Neurosci
Main Authors: Rosenzweig, Ephron S., Salegio, Ernesto A., Liang, Justine J., Weber, Janet L., Weinholtz, Chase A., Brock, John H., Moseanko, Rod, Hawbecker, Stephanie, Pender, Roger, Cruzen, Christina L., Iaci, Jennifer F., Caggiano, Anthony O., Blight, Andrew R., Haenzi, Barbara, Huie, J. Russell, Havton, Leif A., Nout-Lomas, Yvette S., Fawcett, James W., Ferguson, Adam R., Beattie, Michael S., Bresnahan, Jacqueline C., Tuszynski, Mark H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693679/
https://ncbi.nlm.nih.gov/pubmed/31235933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0424-1
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