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Chondroitinase Improves Anatomical and Functional Outcomes After Primate Spinal Cord Injury
Inhibitory extracellular matrices form around mature neurons as perineuronal nets containing chondroitin sulfate proteoglycans (CSPGs) that limit axonal sprouting after CNS injury. The enzyme chondroitinase (Chase) degrades the inhibitory CSPGs and improves axonal sprouting and functional recovery a...
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| Publicado no: | Nat Neurosci |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6693679/ https://ncbi.nlm.nih.gov/pubmed/31235933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0424-1 |
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