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Desymmetrization of Cyclopropenes via the Potassium-Templated Diastereoselective 7-exo-trig Cycloaddition of Tethered Amino Alcohols toward Enantiopure Cyclopropane-Fused Oxazepanones with Antimycobacterial Activity

A strain-release-driven, cation-templated intramolecular nucleophilic addition of tethered alkoxides to prochiral cyclopropenes is described. Employment of chiral β- and γ-amino alkoxides allowed for highly diastereoselective assembly of a small series of enantiopure cyclopropane-fused oxazepanones....

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Maslivetc, Vladimir A., Turner, Danielle N., McNair, Kimberly N., Frolova, Liliya, Rogelj, Snezna, Maslivetc, Anna A., Aksenov, Nicolai A., Rubina, Marina, Rubin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693504/
https://ncbi.nlm.nih.gov/pubmed/29696970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b00640
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