TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/β-catenin degradation and is targeted for GSK3B/GSK3β-mediated phosphorylation and degradation

Aberrant CTNNB1 signaling is one of the fundamental processes in cancers, especially colorectal cancer (CRC). Here, we reported that TRAF6, an E3 ubiquitin ligase important for inflammatory signaling, inhibited epithelial-mesenchymal transition (EMT) and CRC metastasis through driving a selective au...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Wu, Hua, Lu, Xing-Xing, Wang, Jing-Ru, Yang, Tian-Yu, Li, Xiu-Ming, He, Xiao-Shun, Li, Yi, Ye, Wen-Long, Wu, Yong, Gan, Wen-Juan, Guo, Peng-Da, Li, Jian-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693460/
https://ncbi.nlm.nih.gov/pubmed/30806153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1586250
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