Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2(+ve) breast cancer metastasis

BACKGROUND: Human epidermal growth factor receptor-2 (HER2)-targeted therapies prolong survival in HER2-positive breast cancer patients. Benefit stems primarily from improved control of systemic disease, but up to 50% of patients progress to incurable brain metastases due to acquired resistance and/...

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Veröffentlicht in:Breast Cancer Res
Hauptverfasser: Nagpal, Aadya, Redvers, Richard P., Ling, Xiawei, Ayton, Scott, Fuentes, Miriam, Tavancheh, Elnaz, Diala, Irmina, Lalani, Alshad, Loi, Sherene, David, Steven, Anderson, Robin L., Smith, Yvonne, Merino, Delphine, Denoyer, Delphine, Pouliot, Normand
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693253/
https://ncbi.nlm.nih.gov/pubmed/31409375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-019-1177-1
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