Non‐sedating antihistamines block G‐protein‐gated inwardly rectifying K(+) channels

BACKGROUND AND PURPOSE: A second‐generation antihistamine, terfenadine, is known to induce arrhythmia by blocking hERG channels. In this study, we have shown that terfenadine also inhibits the activity of G‐protein‐gated inwardly rectifying K(+) (GIRK) channels, which regulate the excitability of ne...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Chen, I‐Shan, Liu, Chang, Tateyama, Michihiro, Karbat, Izhar, Uesugi, Motonari, Reuveny, Eitan, Kubo, Yoshihiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692640/
https://ncbi.nlm.nih.gov/pubmed/31116876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14717
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