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Non‐sedating antihistamines block G‐protein‐gated inwardly rectifying K(+) channels
BACKGROUND AND PURPOSE: A second‐generation antihistamine, terfenadine, is known to induce arrhythmia by blocking hERG channels. In this study, we have shown that terfenadine also inhibits the activity of G‐protein‐gated inwardly rectifying K(+) (GIRK) channels, which regulate the excitability of ne...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6692640/ https://ncbi.nlm.nih.gov/pubmed/31116876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14717 |
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