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The Pore Helix Is Involved in Stabilizing the Open State of Inwardly Rectifying K(+) Channels

Ion channels can be gated by various extrinsic cues, such as voltage, pH, and second messengers. However, most ion channels display extrinsic cue-independent transitions as well. These events represent spontaneous conformational changes of the channel protein. The molecular basis for spontaneous gat...

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Autori principali: Alagem, Noga, Yesylevskyy, Semen, Reuveny, Eitan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303086/
https://ncbi.nlm.nih.gov/pubmed/12829485
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