Rev-Erbα and Photoreceptor Outer Segments modulate the Circadian Clock in Retinal Pigment Epithelial Cells

Retinal photoreceptor outer segments (POS) are renewed daily through phagocytosis by the adjacent retinal pigment epithelial (RPE) monolayer. Phagocytosis is mainly driven by the RPE circadian clock but the underlying molecular mechanisms remain elusive. Using ARPE-19 (human RPE cell-line) dispersed...

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Udgivet i:Sci Rep
Main Authors: Milićević, Nemanja, Mazzaro, Nadia, de Bruin, Ivanka, Wils, Esmée, ten Brink, Jacoline, Asbroek, Anneloor ten, Mendoza, Jorge, Bergen, Arthur, Felder-Schmittbuhl, Marie-Paule
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692399/
https://ncbi.nlm.nih.gov/pubmed/31409842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48203-3
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