Gut-associated IgA(+) immune cells regulate obesity-related insulin resistance

The intestinal immune system is emerging as an important contributor to obesity-related insulin resistance, but the role of intestinal B cells in this context is unclear. Here, we show that high fat diet (HFD) feeding alters intestinal IgA(+) immune cells and that IgA is a critical immune regulator...

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Publicado en:Nat Commun
Autores principales: Luck, Helen, Khan, Saad, Kim, Justin H., Copeland, Julia K., Revelo, Xavier S., Tsai, Sue, Chakraborty, Mainak, Cheng, Kathleen, Tao Chan, Yi, Nøhr, Mark K., Clemente-Casares, Xavier, Perry, Marie-Christine, Ghazarian, Magar, Lei, Helena, Lin, Yi-Hsuan, Coburn, Bryan, Okrainec, Allan, Jackson, Timothy, Poutanen, Susan, Gaisano, Herbert, Allard, Johane P., Guttman, David S., Conner, Margaret E., Winer, Shawn, Winer, Daniel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692361/
https://ncbi.nlm.nih.gov/pubmed/31409776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11370-y
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