Targeting HIBCH to reprogram valine metabolism for the treatment of colorectal cancer

Valine catabolism is known to be essential for cancer cells but the detailed mechanism remains unclear. This study is to explore the critical roles of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) in colorectal cancers (CRC) and to develop a new therapy returning valine metabolism homeostasis. High HIBC...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Shan, Yunlong, Gao, Yuan, Jin, Wei, Fan, Minmin, Wang, Ying, Gu, Yanhong, Shan, Chenxiao, Sun, Lijun, Li, Xin, Yu, Biao, Luo, Qiong, Xu, Qiang
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692300/
https://ncbi.nlm.nih.gov/pubmed/31409769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1832-6
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