Genetic Silencing of Fatty Acid Desaturases Modulates α-Synuclein Toxicity and Neuronal Loss in Parkinson-Like Models of C. elegans

The molecular basis of Parkinson’s disease (PD) is currently unknown. There is increasing evidence that fat metabolism is at the crossroad of key molecular pathways associated with the pathophysiology of PD. Fatty acid desaturases catalyze synthesis of saturated fatty acids from monounsaturated fatt...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Maulik, Malabika, Mitra, Swarup, Basmayor, Ajiel Mae, Lu, Brianna, Taylor, Barbara E., Bult-Ito, Abel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691153/
https://ncbi.nlm.nih.gov/pubmed/31447665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00207
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