Synthesis of Tris-Heterocycles via a Cascade IMCR/Aza Diels-Alder + CuAAC Strategy

6-Triazolylmethyl-pyrrolo[3,4-b]pyridin-5-one tris-heterocycles were synthesized in 43–57% overall yields. The two-stage synthesis involved a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) followed by a copper-assisted alkyne-azide [3+2] cycloaddition (CuAAC). This efficient and...

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Publicat a:Front Chem
Autors principals: Rentería-Gómez, Manuel A., Islas-Jácome, Alejandro, Pharande, Shrikant G., Vosburg, David A., Gámez-Montaño, Rocío
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691067/
https://ncbi.nlm.nih.gov/pubmed/31448260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00546
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