Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis

Islets transplantation, as a treatment of type 1 diabetes, faces challenges, including the loss of islets in the process of isolation and pre-transplantation due to cellular stresses-induced apoptosis. Accordingly, the optimization of culture plays a decisive role in the transplantation success. In...

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Published in:Sci Rep
Main Authors: Keshtkar, Somayeh, Kaviani, Maryam, Jabbarpour, Zahra, Geramizadeh, Bita, Motevaseli, Elahe, Nikeghbalian, Saman, Shamsaeefar, Alireza, Motazedian, Nasrin, Al-Abdullah, Ismail H., Ghahremani, Mohammad Hossein, Azarpira, Negar
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690971/
https://ncbi.nlm.nih.gov/pubmed/31406275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48262-6
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