Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene expression. Among the Rho GTPases, RhoA, Rac1 and Cdc42 are best characterized. The...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Zahra, Fatema Tuz, Sajib, Md Sanaullah, Ichiyama, Yusuke, Akwii, Racheal Grace, Tullar, Paul E., Cobos, Christopher, Minchew, Shelby A., Doçi, Colleen L., Zheng, Yi, Kubota, Yoshiaki, Gutkind, J. Silvio, Mikelis, Constantinos M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690958/
https://ncbi.nlm.nih.gov/pubmed/31406143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48053-z
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