RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts

RhoA, the founding member of mammalian Rho GTPase family, is thought to be essential for actomyosin regulation. To date, the physiologic function of RhoA in mammalian cell regulation has yet to be determined genetically. Here we have created RhoA conditional knock-out mice. Mouse embryonic fibroblas...

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Библиографические подробности
Главные авторы: Melendez, Jaime, Stengel, Kristy, Zhou, Xuan, Chauhan, Bharesh K., Debidda, Marcella, Andreassen, Paul, Lang, Richard A., Zheng, Yi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083211/
https://ncbi.nlm.nih.gov/pubmed/21454503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.229336
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