RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts

RhoA, the founding member of mammalian Rho GTPase family, is thought to be essential for actomyosin regulation. To date, the physiologic function of RhoA in mammalian cell regulation has yet to be determined genetically. Here we have created RhoA conditional knock-out mice. Mouse embryonic fibroblas...

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Autores principales: Melendez, Jaime, Stengel, Kristy, Zhou, Xuan, Chauhan, Bharesh K., Debidda, Marcella, Andreassen, Paul, Lang, Richard A., Zheng, Yi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083211/
https://ncbi.nlm.nih.gov/pubmed/21454503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.229336
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