Curcumin diethyl disuccinate, a prodrug of curcumin, enhances anti-proliferative effect of curcumin against HepG2 cells via apoptosis induction

Curcumin (Cur) has been reported to have anti-hepatocellular carcinoma activity but its poor oral bioavailability limits its further development as a chemotherapeutic agent. We synthesized previously a succinate ester prodrug of Cur, curcumin diethyl disuccinate (CurDD) with better chemical stabilit...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Muangnoi, Chawanphat, Ratnatilaka Na Bhuket, Pahweenvaj, Jithavech, Ponsiree, Supasena, Wiwat, Paraoan, Luminita, Patumraj, Suthiluk, Rojsitthisak, Pornchai
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690956/
https://ncbi.nlm.nih.gov/pubmed/31406217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48124-1
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