Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice

Previously, we synthesized curcumin and a succinate ester prodrug of curcumin namely curcumin diethyl disuccinate (CurDD) in the lab scale, which yielded hundred milligrams to few grams of the compounds. CurDD was found to be more stable in a phosphate buffer pH 7.4 and exhibited better cytotoxicity...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Pharmaceutics
Egile Nagusiak: Muangnoi, Chawanphat, Ratnatilaka Na Bhuket, Pahweenvaj, Jithavech, Ponsiree, Wichitnithad, Wisut, Srikun, Onsiri, Nerungsi, Chakkrapan, Patumraj, Suthiluk, Rojsitthisak, Pornchai
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6723761/
https://ncbi.nlm.nih.gov/pubmed/31374932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11080373
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