Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice

Previously, we synthesized curcumin and a succinate ester prodrug of curcumin namely curcumin diethyl disuccinate (CurDD) in the lab scale, which yielded hundred milligrams to few grams of the compounds. CurDD was found to be more stable in a phosphate buffer pH 7.4 and exhibited better cytotoxicity...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Muangnoi, Chawanphat, Ratnatilaka Na Bhuket, Pahweenvaj, Jithavech, Ponsiree, Wichitnithad, Wisut, Srikun, Onsiri, Nerungsi, Chakkrapan, Patumraj, Suthiluk, Rojsitthisak, Pornchai
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6723761/
https://ncbi.nlm.nih.gov/pubmed/31374932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11080373
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