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Discovery of 2,3’-Diindolylmethanes as a Novel Class of PCSK9 Modulators

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of low density lipoprotein receptor (LDLR). Anti-PCSK agents have been approved for the treatment of hypercholesterolemia. We recently discovered a series of small-molecule PCSK9 modulators that contains a relatively smal...

詳細記述

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書誌詳細
出版年:Bioorg Med Chem Lett
主要な著者: Winston-McPherson, Gabrielle N., Xie, Haibo, Yang, Ka, Li, Xiaoxun, Shu, Dongxu, Tang, Weiping
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690802/
https://ncbi.nlm.nih.gov/pubmed/31227343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.06.014
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