From Methylene Bridged Diindole to Carbonyl Linked Benzimidazoleindole: Development of Potent and Metabolically Stable PCSK9 Modulators

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a recently validated therapeutic target for lowering low-density lipoprotein cholesterol (LDL-C). Through phenotypic screening, we previously discovered a class of small-molecules with a 2,3’-diindolymethane (DIM) skeleton that can decrease th...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Xie, Haibo, Yang, Ka, Winston-McPherson, Gabrielle N., Stapleton, Donnie S., Keller, Mark P., Attie, Alan D., Smith, Kerry A., Tang, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572704/
https://ncbi.nlm.nih.gov/pubmed/32823006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112678
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