Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK

Autophagy, a membrane-dependent catabolic process, ensures survival of aging cells and depends on the cellular energetic status. Acetyl-CoA carboxylase 1 (Acc1) connects central energy metabolism to lipid biosynthesis and is rate-limiting for the de novo synthesis of lipids. However, it is unclear h...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Gross, Angelina S., Zimmermann, Andreas, Pendl, Tobias, Schroeder, Sabrina, Schoenlechner, Hannes, Knittelfelder, Oskar, Lamplmayr, Laura, Santiso, Ana, Aufschnaiter, Andreas, Waltenstorfer, Daniel, Ortonobes Lara, Sandra, Stryeck, Sarah, Kast, Christina, Ruckenstuhl, Christoph, Hofer, Sebastian J., Michelitsch, Birgit, Woelflingseder, Martina, Müller, Rolf, Carmona-Gutierrez, Didac, Madl, Tobias, Büttner, Sabrina, Fröhlich, Kai-Uwe, Shevchenko, Andrej, Eisenberg, Tobias
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690696/
https://ncbi.nlm.nih.gov/pubmed/31209110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007020
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